The letter published yesterday by the Independent newspaper comes in the run-up to the Sochi Olympics, which have been the focus of a backlash in the West regarding the law.
McKellan known to millions as Gandalf in the "Lord of the Rings" and "Hobbit" films wrote the letter with his friend, chemist Harold Kroto.
Signed by the laureates, it is designed to show the scientific community's "solidarity" with others who have "expressed their abhorrence" at Russia's law.
It bans promotion of "non-traditional sexual relations" to minors and has prompted calls by gay activists and others for a boycott of the games, which begin February 7.
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