The trip comes more than seven decades after the world was first shown the potential keys to its own destruction when an American plane, the Enola Gay, dropped its payload, dubbed "Little Boy" over the western Japanese city.
The bombing claimed the lives of 140,000 people, some of whom died immediately in a ball of searing heat, while many succumbed to injuries or radiation-related illnesses in the weeks, months and years afterwards.
Coming in Obama's final year in office, the visit also marks seven years since he used his trademark soaring rhetoric to call for the elimination of atomic arms in a landmark speech in Prague that helped him win the Nobel Peace Prize.
And while the world today appears no closer to that lofty vision, Obama is expected to use the symbolism of his presence in Hiroshima to call attention to present dangers.
"I want to once again underscore the very real risks that are out there and the sense of urgency that we all should have," he told reporters yesterday at a Group of Seven summit in Japan.
He is to be accompanied by Japanese Prime Minister Shinzo Abe, whose presence would "highlight the extraordinary alliance" forged between Japan and the United States from the ashes of war, Obama said.
Obama is expected to lay flowers at the cenotaph in Hiroshima Peace Memorial Park in the shadow of a domed building, whose skeleton has been left standing in silent testament to the victims of the first ever nuclear attack.
Sunao Tsuboi, 91, a Hiroshima survivor, told AFP that he had been invited to the event.
He earlier told public broadcaster NHK that if he has the chance to speak with Obama, he would "want to express my gratitude" for his visit.
"I have no intention of asking him for words of apology," said Tsuboi, a long-time anti-nuclear campaigner.
Some quarters of Japanese society, however, have called for such a gesture, though Obama has ruled this out and insisted he will not revisit the decisions of his predecessor Harry Truman at the close of World War II.
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