The attacker targeted National People's Party leader Ibrahim Jatoi's convoy at a toll plaza in Shikarpur area this morning.
Jatoi told the media that he was not injured by the blast.
Two of Jatoi's supporters were wounded and two vehicles in the motorcade were destroyed.
Jatoi is contesting polls to a parliamentary seat in Shikarpur area.
Police officials confirmed the attack had been carried out by a suicide bomber.
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At Dera Murad Jamali in Balochistan province, a car bomb went off near the motorcade of independent candidate Allahdino Umrani though there were no casualties.
No group claimed responsibility for both attacks, the latest in a series of bombings targeting politicians and campaign meetings ahead of Pakistan's landmark May 11 general election, which will mark the first democratic transition of power in the country's history.
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