Put in to bat, Gujarat were struggling at 69 for three before Parthiv steadied in the boat, scoring a 176-ball 122, studded with 18 fours.
He also put on a crucial 105-run partnership with Y Venugopal Rao (39) for the fourth wicket.
At stumps, Rujul Bhatt was batting on 27 and Niraj Patel was unbeaten on 17.
For Andhra, DP Vijaykumar was the pick of the wickets with figures of three for 61, while D Siva Kumar chipped in with two for 33.
Gujarat 1st innings: 250 for five in 81 overs (Parthiv Patel 122, Y Venugopal Rao 39, Rujul Bhatt batting 27; DP Vijaykumar 3/61, D Siva Kumar 2/33) vs Andhra.
