Francis issued a special appeal for peace in Iraq at the end of his general audience. He greeted an interfaith group of Iraqis on hand in St Peter's Square, encouraging them in helping Iraq find reconciliation among various ethnic and religious groups.
Francis said that he was particularly concerned about Iraqis trapped by recent fighting to take Mosul back from Islamic State group militants.
"In expressing profound sadness for the victims of the bloody conflict, I renew my appeal that everyone commit themselves to using all efforts to protect civilians, an imperative and urgent obligation," he said.
The UN says IS militants are using human shields and setting a trap for the coalition. Amnesty International has said the rising civilian death toll suggested the US-led coalition wasn't taking adequate precautions as it helps Iraqi forces try to retake the city, though the US has denied any loosening of the rules of combat.
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