"I am sad to learn about the accident in which many have lost their lives and a number of persons are injured, when Indore-Patna Express ran off the tracks near Kanpur in Uttar Pradesh.
"I am sure that the state government is providing all possible assistance to the bereaved families who have lost their near and dear ones as well as medical aid to the injured," Mukherjee said in a message to Ram Naik, Governor of Uttar Pradesh.
The President conveyed his condolences to the family members of the deceased.
Information and Broadcasting Minister M Venkaiah Naidu expressed anguish at the loss of lives.
"It is extremely unfortunate. I am pained at the death of citizens in the accident. I pray for the bereaved families and the injured passengers," Naidu said.
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Vice President Hamid Ansari has expressed grief over the loss of lives in the train accident near Kanpur
"I am deeply grieved and shocked at the tragic loss of life and injuries to passengers resulting from the derailment of the Indore-Patna Express train that took place at Pukhrayan near Kanpur (UP) earlier today.
Union HRD Minister Prakash Javadekar, in Varanasi, termed as "unfortunate" the accident and condoled the death of passengers in the tragedy.
Javadekar said Railways minister Suresh Prabhu and Prime Minister Narendra Modi were closely monitoring the rescue and relief operations.
Senior Congress leader Ghulam Nabi Azad also condoled the loss of lives in the accident.
"It is a tragic incident. I condole the loss of lives and pray for speedy recovery of the injured," he said.