The report titled "Israeli Practices Toward the Palestinian People and the Question of Apartheid" was released by ESCWA at a news conference in Beirut.
Its authors conclude that "Israel has established an apartheid regime that systematically institutionalizes racial oppression and domination of the Palestinian people as a whole. "
Israel's UN Ambassador Danny Danon issued a statement condemning the report.
"The attempt to smear and falsely label the only true democracy in the Middle East by creating a false analogy is despicable and constitutes a blatant lie," he said.
When asked who commissioned the report and who reviewed it, he said: "That's a question to ask of ESCWA. It's a report commissioned by ESCWA, and I would refer your questions to ESCWA."
Rima Khalaf, a Jordanian who heads the Beirut-based agency, which promotes economic and social development in 17 Arab countries, has frequently been criticized by Israel in the past.
In 2015, Israel's ambassador urged the UN's internal watchdog to investigate her, accusing her of "modern day anti-Semitism." The year before, he tried unsuccessfully to get then-Secretary-General Ban Ki-moon to suspend her.
Israeli foreign ministry spokesman Emmanuel Nahshon tweeted that the report should not be read "without anti nausea pills.
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