Activists plan to launch some 10,000 copies of the film -- a comedy about a fictional CIA plot to assassinate North Korean leader Kim Jong-Un whose release infuriated Pyongyang -- as well as 500,000 propaganda leaflets by balloon across the heavily-militarised border on or around March 26.
Pyongyang has long condemned such balloon launches and threatened retaliation, and local residents have complained the activists are putting their lives at risk by making them potential targets.
"If such a movement is detected in advance, the government will take necessary measures because it may threaten the security of residents there," ministry spokesman Lim Byeong-Cheol told reporters.
Seoul insists the activists have a democratic right to send the leaflets, but has appealed for restraint to avoid overly provoking the North.
South Korean police have occasionally prevented the launches at times of high cross-border tensions, citing the possible dangers posed to local residents.
In October last year North Korean soldiers attempted to shoot down some balloons, triggering a brief exchange of heavy machine-gun fire across the border.
The activists remained tight-lipped about the exact location and time for the launch.
