The #DocsOnTwitter study by researchers at Augustana University in the US analysed tweeting habits of medical professionals in the country from 2006 to 2015.
Gupta, with 2,031,428 followers on Twitter, serves as associate chief of the neurosurgery service at Grady Memorial Hospital in Atlanta, Georgia and as assistant professor of neurosurgery at the Emory University School of Medicine.
Gupta, 46, is best known as the chief medical correspondent for CNN and has won multiple Emmy awards. He also uses his Twitter account primarily for professional use, giving his opinions and medical advice.
The group worked with internet research firm BrightPlanet to evaluate Tweets and break the accounts down by age and gender.
The researchers sorted through 4,500 users. The most followed Twitter accounts belonged to celebrities, public figures or TV personalities.
The top three followed doctors on Twitter are: Dr Drew Pinsky (@drdrew) with 3.18 million followers, Dr Gupta (@drsanjaygupta) who has 2.03 million followers, followed by Dr Asa Andrew (@drasa) with 1.03 million followers.
Researchers analysed about 3.4 million tweets to determine when and how physicians were most likely to use Twitter.
The study also shows doctors are using Twitter on the go and are less likely to use the micro blogging site for legal reasons.
Many avoid announcing their personal business on social media because of rules for patient privacy and insurance, according to the report.
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