The 27-year-old opener carried his bat having already hit Afghanistan's first ever century in the format, reaching his hundred off 52 balls with eight fours and eight sixes.
By the end of the blitz, the opener had hit 10 boundaries and faced 67 balls in total to continue his impressive form in the Gulf having already made 131 not out in the second one-day international against Zimbabwe two weeks ago.
Zimbabwe were eventually all out for 134 on Sunday with 11 balls to spare as Afghanistan swept the two-game series having won the first match by just five runs on Friday.
Shahzad's unbeaten 118 was one short of South Africa's Faf du Plessis's 119 against the West Indies in Johannesburg in January last year.
The highest ever score in T20 internationals is Australia's Aaron Finch's mammoth 156 against England in Southampton in 2013 while New Zealand's Brendon McCullum is second on the all-time list thanks to his 123 against Bangladesh in Pallekele in 2012.
"This is my favourite ground, Sharjah, and I like batting here," Shahzad told cricinfo.Com.
"There is no plan. I want to hit every ball out of the boundary. I have got used to Zimbabwe's bowlers. I talked with the captain and we thought 150 would be enough."
But once the big-hitting Masakadza was clean bowled by Rashid Khan in the 16th over, the Africans lost all hope.
"It is our fourth series win against them," said Afghanistan skipper Asghar Stanikzai.
"Phenomenal performance by the guys in the series. In next ten years, I can say Afghanistan will beat any side."
Both sides now head to Bangladesh -- Afghanistan for the Asian Cup qualifiers in February while Zimbabwe tackle the hosts in a four-game T20 series next week.
"The conditions will be similar in Bangladesh -- we will have to make sure we start well in Bangladesh."
Brief scores:
Afghanistan 215-6 in 20 overs (Mohammad Shahzad 118 not out) v Zimbabwe 134 all out in 18.1 overs (Hamilton Masakadza 63, Peter Moor 35).
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