The eight-minute-long terror attack at the two key London landmarks last night came just days before the general election on June 8. The three attackers were shot dead, police said.
The first incident was reported at the London Bridge when a van swerved off the road into a crowd of pedestrians.
A white van driver came speeding veered off the road into the crowds of people who were walking along the pavement, an eye-witness was quoted as saying by BBC.
Six people were killed in the attack, and at least 48 were taken to hospital, the Metropolitan police said.
"We took 48 patients to five hospitals across London and treated a number of others at the scene for minor injuries," London Ambulance Service said in a statement.
"We declared a major incident and continue to work closely with other members of the emergency services at the scene," it said.
The British Transport Police said one of its officers was seriously injured after being stabbed as he responded to the incident, but his condition was not said to be life- threatening.
The three assailants shot dead by police were wearing fake suicide vests, police said today.
"The suspects were wearing what looked like explosive vests but these were later established to be hoaxes," Britain's head of counter-terrorism Mark Rowley said.
A large area of central London remained cordoned off and police told people to avoid the area, leaving tourists and revellers struggling to get home.
Police also said that they were attending a third incident in the Vauxhall area, but later said it was not connected.
It was the third terror attack to strike the UK this year, after a man drove a car into pedestrians on Westminster Bridge in March and the bomb attack on an Ariana Grande concert in Manchester two weeks ago.
Prime Minister Theresa May said that the "terrible incident" in London is being treated as a "potential act of terrorism".
The Indian High Commission in London has set up a Public Response Unit for any Indians caught up in the attack.
"Any Indians injured/affected during the London Bridge 'major incident' and at Borough Market may reach off-office hours Public Response Unit. We shall endeavour to extend all possible assistance to all affected and to their families and friends in this difficult hour," an Indian High Commission statement said.
London Mayor Sadiq Khan called it "a deliberate and cowardly attack on innocent Londoners".
Tim Farron, the Liberal Democrat leader, said: "Tonight's horrific incidents in London remind us how much we owe our emergency services. My thoughts and prayers with everyone affected".
Nicola Sturgeon, the Scottish First Minister and SNP leader, wrote on Twitter: "Dreadful news from London. My thoughts are with all those affected.
The investigation into the latest attack is being led by the Met Police's Counter Terrorism Commandand Britain's Special Air Service (SAS) officers have been deployed in central London.
On May 22, 22 people were killed and 116 injured in a suicide bombing at Manchester Arena.
The attacker, identified as 22-year-old Salman Abedi, detonated a home-made bomb in the arena's foyer as crowds were leaving a performance by US singer Ariana Grande late in the evening. That terror attack stopped election campaigning for three days as troops were deployed to the streets and the UK's terror threat level was raised to "critical", meaning an attack was "imminent".
Attacker Khalid Masood first drove his car at pedestrians on the pavement on Westminster Bridge before crashing into a perimeter fence. Masood, armed with a knife, then left the vehicle and ran towards Parliament, where he was shot dead by police.
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