The government has announced the shutdown, with the population of six million confined to their homes except for essential business, for 72 hours starting from September 19.
More than 20,000 volunteers will go door-to-door to remove bodies and take patients who have not yet gone to hospital into the care of medics.
The government's Ebola emergency operation centre said 10 areas of the capital Freetown had been designated as "hot spots" charged with dealing with the surge in cases expected.
The Ebola outbreak has killed almost 2,300 people in four west African nations.
Sierra Leone has reported some 500 deaths from almost 1,400 cases since it registered its first infection in May.
The government has set aside USD 1.3 million (1.0 million euros) to cover the costs of the shutdown, most of which has been donated by the United Nations Children's Fund, according to health ministry spokesman Yahya Tunis.
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