The bomber walked up to the home of Hashmat Khalil Karzai to greet him after morning prayers for the Eid al-Fitr holiday, and detonated the explosives after shaking hands with the president's cousin, said the official.
No one immediately claimed responsibility for the attack, which was reminiscent of the September 2011 killing of former Afghan President Burhanuddin Rabbani, who at the time was the leader of a government-appointed peace council seeking reconciliation with militants.
Today's attack took place at the reception room for guests at the Karzai family home in southern Kandahar province's district of Karz, according to Dawa Khan Minapal, the provincial governor's spokesman.
Hashmat, a political figure in his own right, has been his cousin's staunch supporter and has also backed former Finance Minister Ashraf Ghani Ahmadzai's bid to succeed President Karzai.
It was not the first time that Karzai's family members have been targeted. The president's powerful half-brother, Ahmad Wali Karzai, who was the head of the provincial council, was slain in his home in the city of Kandahar by his bodyguard in July 2011.
The two presidential contenders, Ahmadzai and former Foreign Minister Abdullah Abdullah, are awaiting the results of the audit.
President Karzai yesterday appealed for a speedy conclusion to the audit that will determine his successor, saying that Afghanistan urgently needs a new president. His slain cousin Hashmat ran a private security company and was also on Ahmadzai's election campaign team as campaign manager for Kandahar.
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