The assailants first set off the two massive truck bombs outside the government compound in the provincial capital of Ghazni, followed by a full frontal assault by over a dozen gunmen.
The assault triggered a gunbattle with the policemen and security forces at the compound and officials said all 13 assailants were subsequently killed. The Taliban claimed responsibility for the attack in a text message sent to the media.
Two candidates vying to succeed President Hamed Karzai pulled their observers out of a ballot audit meant to determine the winner of a June runoff.
The attack also came as a NATO summit was to begin in Wales, where alliance leaders are to discuss the final stages of the 13-year Afghan war.
All foreign combat troops are expected to leave Afghanistan by the end of the year. The US continues to draw down its forces in the country from a high of around 100,000 three years ago to a current force of 30,000. The US plans to lower troop numbers down to about 10,000.
"Those elections that the foreigners considered the fruition of their 13-year-old occupation is now seen as a historical shame," the group said. "It was planned that Afghanistan's next leader would participate in the Wales Summit. Now their plans have come to naught."
The truck bombs in Ghazni blew out many windows across the city, and left about 80 people hurt, mostly from flying glass, said Gov. Musa Khan Akbarzada. He said one truck carved a 10-metre (yard) hole into the ground.
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