Joan Kagezi, acting assistant director of public prosecution, was assassinated by men on a motorbike early Monday evening as she was driving home in a suburb of the capital, Kampala police spokesman Patrick Onyango said.
"They were trailing her on a motorcycle.... They shot her dead," Onyango said.
The July 2010 suicide bombings targeted football fans watching the World Cup final at a restaurant and a rugby club in Kampala. Somalia's Al-Qaeda-affiliated Shebab militants claimed responsibility for the attack, the group's first outside Somalia.
All but one have also been charged with belonging to the Shebab.
Jane Kajuga, spokeswoman for the office of the director of public prosecution, confirmed the death of Kagezi, who led the prosecution's anti-terrorism and war crimes section.
"She has been shot dead... But details are so far scanty," Kajuga told the NTV Uganda station.
The July 2010 attack was one of the deadliest by the Shebab, who also carried out the 2013 assault on the Westgate Mall in Nairobi, Kenya, killing at least 67 people.
Al-Shebab continues to target countries in the region.
In September Ugandan security forces seized suicide vests and explosives during a raid on a suspected Shebab cell in Kampala.
Last week Uganda said it was boosting security over threats by the Shebab, after the US embassy in Kampala warned its citizens of a possible imminent terror attack.
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