The third and final debate was characterised by heated exchanges between the 70-year-old Republican candidate and his Democratic rival Hillary Clinton.
Trump dismissed as "totally false" the sexual assault allegations against him and insisted that Clinton's husband Bill has been accused of worse attitudes towards women and she should be held accountable for him.
Clinton said: "Donald thinks belittling women makes him bigger. He goes after their dignity, their self-worth, and I don't think there is a woman anywhere who doesn't know what that feels like."
He repeated: "Nobody has more respect", prompting debate moderator Chris Wallace to try and hush the crowd, urging: "Please, everybody."
Trump has been accused of various accounts of sexual harassment.
A 2005 video, obtained by the Washington Post, captures Trump having an extremely lewd conversation about women.
It was after the emergence of the video that Trump's presidential campaign has been jolted with Clinton taking a substantial lead over him in national opinion polls.
Trump is also facing accusations of sexual assault and inappropriate touching, with as many as nine women coming out with allegations against him.
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