"The worst-case scenario that could happen in this region in the short term would be a new influx of 600,000 refugees at the Turkish frontier," Kurtulmus told journalists following a cabinet meeting.
The clashes in the north of Aleppo province -- sparked by a week-long government assault with Russian air support -- have displaced tens of thousands of people.
"As a consequence of this situation, we are seeing 200,000 people being forced to flee -- 65,000 in the direction of Turkey and 135,000 inside Syria," Kurtulmus said.
Huge crowds of refugees, mainly women and children, have been forced to wait at the Oncupinar border crossing, which remains closed with only medical emergencies allowed through.
"Our objective for now is to keep this wave of migrants on the other side of Turkey's borders as much as is possible, and to provide them with the necessary services there," Kurtulmus said.
The Turkish government has insisted for several days that its open-door policy to refugees fleeing the Syrian war remains unchanged and that it is ready, if necessary, to accommodate a new wave of arrivals.
But he added that his country, which is hosting some 2.7 million Syrian refugees, should not be expected "to shoulder the refugee issue alone.
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