"We have made an extremely tough decision: we plan to part ways with up to 336 people from across the company," Dorsey in a letter to employees.
"We feel strongly that engineering will move much faster with a smaller and nimbler team, while remaining the biggest percentage of our workforce," he said, adding that the rest of the organisation will be streamlined in parallel.
He said the team has been working around-the-clock to produce streamlined roadmap for Twitter, Vine, and Periscope and they are shaping up to be strong.
Dorsey said the "roadmap is also a plan to change how we work, and what we need to do that work".
He added that product and engineering are going to make the most significant structural changes to reflect the microblogging company's plan ahead.
Twitter brought back Dorsey two weeks back with a hope that he would be able to resolve financial problems and boost profits.
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