Financial markets illustrated the turbulence that could lie ahead for the world's fifth biggest economy, with the pound collapsing to its lowest level against the dollar since 1985 and equity investors nursing heavy losses.
Campaigners wanting Britain to remain part of the European Union argued long and hard about the economic risks of Brexit, but ultimately failed to convince a majority of voters in Thursday's referendum.
The UK must now face up to the swirling winds of economic change, as International Monetary Fund chief Christine Lagarde called on Britain and Europe to work together to ensure that the pullout will occur smoothly.
"It's been a bloodbath. Carnage," said David Papier, head of sales trading at ETX Capital, with shares in British lenders Barclays and state-rescued Royal Bank of Scotland losing around a third of their value in early deals.
The many political uncertainties linked to the lengthy exit process are also set to impact Britain's economy in the medium to long-term, according to experts.
Conservative Prime Minister David Cameron -- who campaigned for Britain to remain -- announced his resignation today after losing the referendum and plans to step down by October.
Campaigners and supporters of Brexit downplayed this and many other warnings on the economic fallout of Britain's departure from the bloc.
Nevertheless, the World Trade Organisation has predicted that British exporters risk an extra 5.6 billion pounds (USD 8.2 billion, 7.2 billion euros) of extra annual customs duties following Brexit.
Whether these are lifted during Britain's period of transition remains to be seen, while the country's banking and car manufacturing sectors have made it clear that jobs would have to be relocated abroad because of the vote's outcome.
JPMorgan employs 16,000 people in Britain, while chairman and chief executive Jamie Dimon previously said that up to 4,000 jobs could move out of the UK.
Following an EU exit, London could shed 100,000 jobs, according to finance lobbyists TheCityUK ahead of the vote.
"There are a number of large companies that say they are using the UK as a gateway to Europe and a number of companies have said that they would relocate their headquarters in the event of a Brexit -- moving out of London to other financial centres in Europe," said Scott Corfe, a director at the independent Centre for Economics and Business Research.
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