There have been over 9 million cases of malaria in the East African nation since January 2016, according to the report by the UN humanitarian office. Burundi, one of the world's poorest countries, has a population of about 11 million.
The malaria cases are "well beyond the epidemic threshold," the report said, citing World Health Organization investigators.
The outbreak is the latest crisis for Burundi, which has been wracked by deadly political violence since 2015 and faces food shortages that the UN says have left nearly one in 10 people severely food insecure.
Hundreds have been killed, and more than 380,000 Burundians have fled into neighboring countries.
The UN estimates that the number of people affected by food insecurity increased from 2.1 million to 3 million between October and January, the report said.
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