The 81-year-old, who has played mild-mannered Ken Barlow in "Coronation Street" since the soap's first episode in 1960, was found not guilty of two counts of rape and four counts of indecent assault.
Roache had denied the claims, which involved five girls aged between 11 or 12 and 16.
The three-week trial heard allegations that he had used his fame to assault teenage girls in his television studios in the 1960s and then force them to remain silent.
"In these situations there are no winners and I think we should all be much kinder to ourselves," he said.
"Now if you'd excuse me I'd like to get back to work."
ITV took him off the show while legal proceedings against him were under way.
Guinness World Records lists Roache as the longest serving soap actor in the world.
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