This is UNICEF's first such alert on Yemen, where a Saudi-led coalition has been fighting Shiite Houthi rebels since late March.
The report says that as of a week ago, 398 children have been killed, 377 have been recruited to fight and 1.3 million have fled their homes.
Human rights groups have expressed concern that both sides are violating the laws of war and not doing enough to protect civilians.
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