LinkedIn's shares were set to open more than 30 percent lower at around $128, representing a loss of more than $8 billion in market value. The drop would be the stock's sharpest decline since the company went public in 2011.
At least seven brokerages downgraded the stock from "buy" to "hold" or their equivalents, saying the company's lofty valuation was no longer justified.
"With a lower growth profile, we believe that LinkedIn should not enjoy the premium multiple it has grown accustomed to," Mizuho Securities USA Inc analysts wrote in a note.
Mizuho downgraded the stock to "neutral" and slashed its target price to $150 from $258.
Raymond James, Cowen and Co, BMO Capital Markets, J.P.Morgan Securities and RBC Capital Markets also downgraded the stock.
At least 22 brokerages cut their price targets on the stock, with RBC slashing its target by almost half to $156.
LinkedIn forecast full-year revenue of $3.60-$3.65 billion, missing the average analyst estimate of $3.91 billion, according to Thomson Reuters I/B/E/S.
"This would imply that LinkedIn will grow around 15 percent in 2017 and 10 percent in 2018," the Mizuho analysts said.
Underscoring the slowdown in growth, LinkedIn said online ad revenue growth slowed to 20 percent in the fourth quarter from 56 percent a year earlier.
RBC analysts said they had thought LinkedIn was on the cusp of "fundamentally positive" change.
"We were wrong," they said in a client note.
As of Thursday, LinkedIn shares were trading at 50 times forward 12-month earnings versus Twitter Inc's 29.5 times, Facebook Inc's 33.8 and Alphabet Inc's 20.9, making it one of the most expensive stocks in the tech sector.
Facebook, Alphabet and Amazon.com Inc are better picks for investors than LinkedIn, Evercore analysts wrote.
LinkedIn has been spending heavily on expansion by buying companies, hiring sales personnel and growing outside the United States, but is now facing pressure in Europe, the Middle East, Africa and Asia-Pacific due to macro-economic issues.
"Given those macro concerns and LinkedIn's recent execution issues, we expect investors will demand financial outperformance before there is meaningful recovery in LNKD's multiple," Goldman Sachs analysts wrote in a client note.
LinkedIn shares have lost nearly a quarter of their value in the last three months.
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