Los Cuatro Fantasticos, as fans call them, are all 26, came through Argentina's ranks together and are hitting the peak of their careers.
Coach Alejandro Sabella is spoiled for choice as he takes his fancied team to the World Cup to take on Nigeria, Bosnia and Iran in Group F.
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Higuain, of Italian side Napoli, has 22 goals from 36 internationals; Aguero, who has just won the English title with Manchester City, 21 goals from 50 games and Di Maria, triumphant in the Champions League with Real Madrid, 11 goals from 45 games.
Sabella could play them any way he wants and that kind of firepower has made Argentina second favourites to win the cup, behind Brazil. The coach struggled however to get the right formation after he arrived in September 2011.
"Today the team plays with three attackers (Messi, Aguero and Higuain) of an extraordinary level, plus di Maria, who is a fourth attacker," said Sabella.
Di Maria normally plays an offensive midfield role for Argentina.
"It is very difficult to take one out," Sabella added. "But we are going to continue like this."
Even if one of the fab four is injured, Sabella has plenty of support to fall back on. Carlos Tevez could not even make the Argentine squad despite a brilliant season with Juventus. Sabella could not handle managing a squad with Messi and Tevez.
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