"Constructive engagement (in addition to) tireless efforts by negotiating teams are to open new horizons," Rouhani said on Twitter after intensive talks in Geneva produced a long-elusive accord.
Rouhani said the deal had been made possible due to "Iranian people's vote for moderation", referring to his surprise election victory in June.
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The talks had hit snags over few points of difference, including Iran's insistence to have what it calls its "right" to enrich uranium to be recognised by the six major powers.
The White House said such a right was not inserted in the deal, while a senior Iranian negotiator, Abbas Araqchi, said Iran's "enrichment programme" had been recognised.
"Our enrichment programme has been recognised," Araqchi, a deputy foreign minister, said on Twitter but did not elaborate.
His boss Mohammad Javad Zarif said on Facebook that Iran's nuclear activities were to continue while "sanctions were not in decline".
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