New York's main contract, West Texas Intermediate for delivery in September, was down 27 cents at $106.96 a barrel in mid-morning trade, while Brent North Sea crude for September shed 22 cents to $108.20.
Banking giant HSBC said its preliminary purchasing managers index (PMI) for China hit an 11-month low of 47.7 for July, down from 48.2 in June.
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"The negative Chinese PMI data is having a dampening effect on oil prices," Jason Hughes, head of sales trading at CMC Markets in Singapore, told AFP.
"Traders will also be closely watching out for PMI data from Europe and elsewhere for clues about global demand," he said.
The result is the latest in a string of data suggesting previous double-digit growth rates in the world's top energy consumer are a thing of the past as Beijing looks to shift its income source from exports to domestic consumption.
Investors will now look to the release of the weekly US crude stockpiles by the Department of Energy later Wednesday.
A survey by the American Petroleum Institute showed supplies fell 1.44 million in the week to July 19, signalling robust demand as Americans take to the roads for their holidays.
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