Shortly before passing the baton to his successor James Comey on September 4 -- a dozen years to the day since becoming director -- Mueller spoke to several media outlets, including AFP.
Under his leadership, the US Federal Bureau of Investigation has evolved considerably, from an agency probing past attacks to one whose "number one priority" was to prevent them.
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"I had in my own mind some ideas where the Bureau needed to go -- and a week later we had September 11."
"I did not expect that I'd be spending my time preventing terrorist attacks," he added.
During the upheaval of the US security apparatus that followed, the FBI saw its prime focus turn to anti-terrorism.
At the time, 2,000 out of 11,000 special agents were immediately transferred from fighting crime to combatting Al-Qaeda. Since then, the number of intelligence analysts at the FBI has more than tripled.
Over time, the danger posed by Al-Qaeda and its affiliates has evolved but, together with cyber threats, will remain "our number one priority for the foreseeable future."
While Al-Qaeda "was badly diminished, decimated," there was growth in other satellites after 2001 -- including the Somali Islamist group Shebab and Al-Qaeda in the Arabian Peninsula (AQAP) in Yemen, Mueller said.
One of Mueller's many accomplishments was the foiling of an attack -- planned by AQAP -- on a commercial airliner bound for Detroit on Christmas Day 2009.
Mueller expressed concern about the "shifting landscape in terms of the countries involved in the Arab Spring -- Tunisia, Libya, Mali, to a lesser extent Algeria, Syria and, quite obviously in the last two months, Egypt."
"Every one of these countries has individuals who you would put in the category of violent extremists that present threats down the road, not just to the US but to Americans overseas," he said.
Mueller also expressed concern about the threat posed by so-called "lone wolf" attackers who often become radicalized and learn how to make bombs online.
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