The NSE Nifty closed below the 8,100-mark by falling 45.95 points, or 0.57 per cent, to 8,065.80 -- also its lowest closing since October 1.
On a weekly basis, the Sensex lost 813.98 points, or 3.05 per cent, and the NSE Nifty plunged 229.70 points, or 2.84 per cent -- their worst weekly performance in two months.
"Market was dragged down by subdued quarterly earnings by key corporates like capital goods major Larsen & Toubro and FMCG heavyweight ITC. Breakdown of commodity prices across the world, weak global cues and a weak rupee weighed on sentiment," said Gaurav Jain, Director, Hem Securities.
Sectorally, the BSE capital goods index was hit the hardest, down 2.65 per cent, followed by FMCG, realty, auto and metal.
Broader markets too came under pressure, with the BSE small-cap losing 0.78 per cent and mid-cap 0.13 per cent.
Meanwhile, foreign investors bought shares worth Rs 174.12 crore on Thursday, as per provisional data.
Earlier in the day, major Asian indices ended mixed amid concerns over the US Fed's rate hike trajectory as it indicated raising rates at its policy-setting meeting due in December.
European stocks were trading a tad lower in their early trade, taking cues from Asia.
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