Three masked men on motorcycles threw the firebombs into the club in the Agouza district early this morning and fled, a security official was quoted as saying by state-run MENA news agency.
Several people were injured in the attack, the official said. The injured were transferred to a hospital.
The unidentified attackers torched the club by throwing Molotov bottles on it.
The club, located about 5km from Tahrir Square in downtown Cairo, also houses a restaurant.
The source said police has intensified the search for the attackers.
Cairo has previously been rocked by a series of attacks on security forces and civilians carried out by suspected Islamist militants.
An Islamist insurgency intensified in the wake of the overthrow of President Mohammed Morsi in 2013.
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