The explosive device was planted in a rickshaw parked outside the cable operator's office in Muzaffarabad Colony of Landhi area.
The bomb was triggered by remote control at about 2 am, police officials said.
The dead and injured were taken to a nearby hospital.
Police in Karachi also claimed to have shot dead a Taliban operative who was reportedly involved in the killing of Parween Rahman, a well-known social worker, on Wednesday.
They said six more Taliban militants were arrested during raids yesterday.
Officials claimed one of the arrested militants was one of the masterminds behind the bomb attack on Abbas Town, a Shia-dominated area, that killed nearly 50 people.
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