Delta was the first carrier to halt flights to and from Israel after diverting a flight carrying 273 passengers bound for Ben Gurion airport to Paris after a rocket from Hamas- controlled Gaza Strip landed near Israel's biggest airport.
It was followed by America's Federal Aviation Administration (FAA) - which has halted all US flights to and from Israel - Air France and Dutch airline KLM.
The decision is likely to deliver a substantial blow to Israel's tourism industry, the one sector that has already suffered during the conflict.
The Israeli military said it hit more than 187 targets overnight, most of them in Shaja'ia, a neighborhood east of Gaza City near the border with Israel. The IDF says Hamas uses the residential area as a "fortress for its weapons, rockets, tunnels and command centers."
The death toll mounted as neither side showed any sign of backing down.
Palestinian health officials said at least 640 Palestinians had been killed and 4,040 wounded. Some 70 to 80% of them are civilians, according to the UN.
Twenty-nine Israeli soldiers and two Israeli civilians were also killed in the conflict.
United Nations Relief and Works Agency (UNRWA) said more than 118,300 Palestinians have now taken refuge in its shelters. It says 43% of Gaza has been affected by evacuation warnings or declared no-go zones.
On US President Barack Obama's direction, US Secretary of State John Kerry yesterday held talks with Egyptian and Arab League officials in Cairo to push for an "immediate cessation of hostilities".
In Jerusalem, UN Secretary-General Ban Ki-moon met Israeli Prime Minister Benjamin Netanyahu, who showed him a collection of rockets that had been fired into his country.
Ban called the evidence "quite shocking" and called for an immediate end to the attacks.
But he also criticised Israel over its military campaign, saying it "will not increase Israel's stability and security in the longer term."
Netanyahu, argued there's little Israel can do to satisfy Hamas.
Ban, however, in a video link to the UN Security Council in New York from Ramallah suggested that a breakthrough could be imminent, although he could not disclose details "at this highly sensitive moment".
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