The 32-year-old actress, who played the titular role of Betty Suarez on the show, said she had "so much gratitude" for her years in the role, adding that herself and the character "grew up together", reported Digital Spy.
She also posted a photo of her "last day at Mode over 6 years ago", as well as posting a throwback photo with crew members.
She later reunited with her former cast mates Eric Mabius, Vanessa Williams, Becki Newton, Michael Urie, Ashley Jensen, Ana Ortiz, Tony Plana, Mark Indelicato, and Rebecca Romijn for a reunion panel at ATX.
It followed Betty, a girl with no style who lands a job at a top fashion magazine.