West Indies, who won the toss, were 35 for two at lunch on the first day of the third and deciding Test with a three- match series all square at 1-1.
England spearhead Anderson, who started this match on 497 Test wickets, had lunch figures of two for 18 in 10 overs after removing both Kraigg Brathwaite and Kyle Hope with the aid of catches by wicket-keeper Jonny Bairstow.
Kieran Powell was 17 not out and Shai Hope eight not out.
Anderson, who went wicketless in the second innings at Leeds, should have had his 498th Test wicket when he took Brathwaite's outside edge when the opener, who made 134 and 95 at Headingley, was on three.
But Alastair Cook, who floored two first-slip catches as West Indies chased 322 for victory last week, dropped a seemingly routine chance.
Rain then stopped play for some 40 minutes and when the match resumed Anderson had Kyle Hope out for a duck when the batsman, trying to withdraw his bat, was well caught by Bairstow diving to his right, in front of Cook.
Anderson had taken two wickets for no runs in 12 balls and West Indies were 22 for two.
Hope's exit brought in younger brother Shai Hope fresh from scores of 147 -- his maiden Test century -- and a match- winning 118 not out in Leeds.
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