The increasing use of suicide bombers -- often young women and girls forced to carry and detonate explosives in crowded areas -- has killed at least 381 civilians in the two countries, the rights group said in a statement.
"Boko Haram is once again committing war crimes on a huge scale, exemplified by the depravity of forcing young girls to carry explosives with the sole intention of killing as many people as they possibly can," said Alioune Tine, Amnesty International's director for West and Central Africa.
Amnesty said at least 223 civilians died in Nigeria since April, underscoring that the real toll could be far higher.
"Between May and August, seven times more civilians were killed than in the preceding four months, while 100 civilians were killed in August alone," it said.
Boko Haram is waging an insurgency in a bid to establish a hardline Islamist state in Nigeria's mainly Muslim north.
More than five million people are starving as the fighting has devastated farmland, leaving farmers unable to sow or cultivate crops for several years.
In neighbouring Cameroon, Amnesty said since April at least 158 civilians died in Boko Haram strikes, a figure four times higher than the preceding five months.
"The recent spike in casualties has been driven by increased suicide attacks, with 30 -- more than one per week -- carried out since the beginning of April," it said.
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