The five men were arrested on suspicion of being concerned in the commission, preparation or instigation of acts of terrorism, West Midlands Police said.
"The arrests were intelligence-led and part of an ongoing investigation," a spolice spokesperson said.
"Police are searching a number of properties in the Stoke and Birmingham areas as part of the investigation; these searches are on-going," he added.
Police say that, as a result of one of the arrests, an Army bomb disposal team has been called in as "a precautionary measure".
Police raided three homes in Birmingham and made two linked arrests in Stoke-on-Trent.
Two men, aged 18 and 24, were arrested at their homes in Birmingham and a 28-year-old man was detained in a different area of the city.
Another two men, aged 32 and 37, were arrested in Stoke.
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