Official news agency SANA said the bomb detonated at the entrance of a building near central Hijaz square at midday. Eight people were killed and at least 50 were wounded in the blast, it added. It quoted unmanned officials as blaming "terrorists" for the attack, a term used by President Bashar Assad's government to refer to the rebels fighting to overthrow him.
In a similar incident southeast of the capital, state-run Al Ikhbariya TV said an explosion went off in the city of Sweidah, causing a number of casualties. It did not give a number. If confirmed, it would be the first attack targeting a predominantly Druse city.
There was no immediate claim of responsibility for today's attacks.
Rebels fighting to topple President Bashar Assad have frequently targeted Damascus with bombs. Armed opposition fighters tied to al-Qaeda have previously claimed bombings of government and security institutions in the capital and beyond.
