The summit -- bringing together the 15 CARICOM member states and Cuba -- aims to increase trade and cooperation within the group and with Cuba.
"We continue to stand with Cuba on the United States embargo against Cuba," said Antigua and Barbuda Prime Minister Gaston Browne, who chairs CARICOM.
"I call on President (Barack) Obama to lift that senseless, that senseless embargo now," he added at a welcoming ceremony at the airport.
A leaders summit takes place today, preceded by talks between foreign ministers yesterday.
The United States and Cuba have lacked full diplomatic relations since 1961. In 1962, Washington imposed an economic embargo on the island, the only Communist-run country in the Americas.
The United States, which is also invited to the April summit, said it was not worried about Cuba's participation.
"I think what we're focused on is less on who's invited and more on what's discussed," said State Department spokeswoman Marie Harf.
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