"The French air strike (on Sunday) on an IS training camp in eastern Syria killed at least 30 IS fighters including 12 from the 'Cubs of the Caliphate,'" said Rami Abdel Rahman of the Syrian Observatory for Human Rights.
IS calls its child soldiers "Cubs of the Caliphate".
Abdel Rahman said foreign IS fighters were also among the dead, and that the strike had wounded around 20 people.
The raid took place in Syria's eastern province of Deir Ezzor, near the Albu Kamal border crossing used by IS to link the Syrian and Iraqi parts of its so-called "caliphate".
"We struck militarily an extremely sensitive site for (IS)," said French Defence Minister Jean-Yves Le Drian, describing it as a "strategic hub" for militants travelling between Iraq and Syria.
It was France's first air strike in Syria as part of the US-led coalition fighting the extremist group there and in Iraq.
France was already bombing IS targets in Iraq and had carried out 215 of the nearly 4,500 air strikes there.
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