Hicks, 29, is leaving the White House after serving Trump for three years in various capacities. This included being his campaign spokesperson and Director of Strategic Communication when Trump was sworn in as the president on January 20, 2017.
The announcement of her resignation came a day after she testified before the House Intelligence Committee on allegations related to the Russian interference during the 2016 presidential campaign.
The White House did not announce her exact day of resignation.
"Her departure is to be determined but it will be sometime in the next few weeks," it said.
After three years, she approached Trump and told him she wanted to leave so she could start exploring opportunities outside of the White House.
On his part, Trump was effusive in his praise for Hicks.
"Hope (Hicks) is outstanding and has done great work for the last three years. She is as smart and thoughtful as they come, a truly great person," Trump said.
"I will miss having her by my side but when she approached me about pursuing other opportunities, I totally understood. I am sure we will work together again in the future," he said.
In this position, Hicks led strategic messaging for administration priorities such as the historic passage of tax reform and worked with Press Secretary Sarah Sanders to stabilise the press and communications teams after initial phases of transition.
"There are no words to adequately express my gratitude to President Trump. I wish the president and his administration the very best as he continues to lead our country," Hicks said in a statement.
The White House said Hicks is a "valued adviser and counselor to the president and other senior administration officials".
"She became a trusted adviser and counselor and did a tremendous job overseeing the communications for the president's agenda, including the passage of historic tax reform. She has served her country with great distinction. To say that she will be missed, is an understatement," Kelly said.
Sanders said Hicks would leave behind a void which nobody can fill.
"She is in a league of her own and no one can replace her. Far and away one of the most talented and skilled people Ive ever met and coming to work wont be the same without her," Sanders said.
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