US Secretary of State John Kerry was meanwhile holding talks in Moscow to push for peace efforts in Syria, from where IS has claimed attacks on the West including this week's bombings in Brussels.
Backed by Russian warplanes and allied militia on the ground, the Syrian army advanced into Palmyra today after launching a desert offensive early this month, the Syrian Observatory for Human Rights monitoring group said.
IS overran Palmyra -- known as the "Pearl of the Desert" -- last May and it has since blown up UNESCO-listed temples and looted relics that dated back thousands of years.
A Syrian military source confirmed the advance into the city, saying the army had entered from the northwest after seizing control of part of the historic Valley of the Tombs.
"The clashes, which are ongoing, are fierce," he told AFP.
Syria's antiquities chief Maamoun Abdelkarim hailed the "imminent" recapture of Palmyra, vowing to rebuild monuments the jihadists destroyed.
"I am so happy that the liberation is imminent... And that the nightmare is nearly over, before it is too late, before the total destruction of the ancient city," he told AFP.
IS had earlier urged civilians to flee the city, where about 15,000 of its 70,000 original residents remained after the jihadist takeover.
Palmyra's recapture would be a major strategic and symbolic victory for President Bashar al-Assad, since whoever holds it also controls the vast desert extending from central Syria to the Iraqi border, experts say.
Across the border, Iraqi forces announced the start of an offensive to retake the second city of Mosul, IS's main hub in Iraq.
The army and the Popular Mobilisation paramilitary force "have begun the first phase of conquest operations" in the northern Nineveh province, of which Mosul is the capital, Iraq's joint operations command said in a statement.
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