The eight-hour walkout will go from 9 a.M to 5 p.M and hit long-haul flights, the pilots' union Cockpit said in a statement today.
No flights will take off from Frankfurt, the airline's biggest hub, it added.
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"We regret any inconvenience to Lufthansa customers."
The airline has been hit by several rounds of industrial action over its plans to change the early retirement policy.
A strike last Wednesday grounded 110 flights across Europe, affecting some 13,500 passengers.
The three walkouts taken together have forced the cancellation of 475 flights in total, almost entirely on domestic and European routes.
Due to advance notice, the industrial action has not sparked chaos at German airports. But it has dealt a heavy blow to Lufthansa, which already incurred losses of around USD 78 million from three days of strikes in April.
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