Latifah, 43, will be honoured on April 28 at the Waldorf Astori along with eight others.
"Queen Latifah was chosen not only for what she has done, but also for what she has given back, as her work and career are an inspiration to all women who are trying to change the world for the better," said the organization.
Past Matrix winners include Meryl Streep, Tina Fey, Robin Roberts, Ellen DeGeneres, Martha Stewart, Whoopi Goldberg and Meredith Vieira.
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