The 30-share index has now lost over 602.34 points in the last three days after rising to 29,000-levels on Monday.
Shares of TCS plunged 4.22 per cent, its biggest fall since October, after country's largest software exporter posted lower-than-expected earnings in the March quarter.
"Looking at Q4FY15 numbers, consensus earnings for Sensex has been lowered to 3.5 per cent YoY from 9 per cent a month ago. In the same time market is concerned at downgrading FY16E numbers by 3-5 per cent (Sensex EPS)," said Vinod Nair, Head of Fundamental Research at Geojit BNP Paribas Financial Services.
It finally settled 223.94 points or 0.78 per cent lower at 28,442.10.
The gauge had closed at 28,260.14 on April 1.
The 50-share NSE Nifty also dropped by 100.70 points or 1.16 per cent to close the day at 8,606.00 after shuttling between 8,699.85 and 8,596.70 intraday.
On losers on the Sensex included, Wipro, Infosys, Sun Pharma, Axis Bank, Bharti Airtel, GAIL, Bajaj Auto, Hero MotoCorp and HDFC Bank.
Tata Steel, Sesa Sterlite, Hindalco, BHEL, NTPC, Tata Power and Hind Unilever also rose on the day.
Globally, Asian markets ended in negative zone, while European markets were higher in their early trade.
Sectorwise, the BSE healthare index suffered the most by plunging 3.05 per cent, followed by teck at 2.02 per cent, IT 2 per cent, consumer durable by 1.80 per cent, bankex 1.64 per cent, auto 1.13 per cent, realty 0.84 per cent, capital goods 0.74 per cent and oil & gas 0.36 per cent.
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