The 30-share barometer fell 93.42 points, or 0.34 per cent, to 26,946.34 after opening in positive zone. The gauge had lost 431.03 points in the previous three sessions.
Losses in FMCG, banking, power, PSU, IT, capital goods and oil&gas stocks dragged the Sensex down.
Also, the NSE Nifty declined 23.65 points, or 0.28 per cent, to 8,147.55.
Brokers said squaring-up of positions by participants with today being the last trading session of the October derivatives expiry dampened sentiment.
Hong Kong's Hang Seng was down 0.39 per cent, Japan's Nikkei fell 0.14 per cent, while Shanghai Composite shed 0.09 per cent in early trade today.
The Dow Jones Industrial Average ended 1.13 per cent higher in yesterday's trade.
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