The 30-share barometer fell 188.30 points, or 0.76 per cent, to 24,470.93, with metal, banking, IT, consumer durables, capital goods, PSU and oil and gas falling the most.
The index had gained 1,657.23 points in the last five sessions.
Also, the NSE Nifty dropped 49.85 points, or 0.67 per cent, at 7,435.45.
Brokers said that apart from profit-booking in recent gainers, a weak Asian trend as fresh concerns about global growth driven by weak Chinese trade data hit sentiment here.
The Dow Jones Industrial Average ended 0.64 per cent lower in yesterday's trade after oil prices fell.
