Details on casualties were not immediately known after the sixth attack in the key northern city in the last week, with the violence blamed on Boko Haram Islamists who are waging a brutal five-year insurgency.
The bomber targeted students who had crammed around a notice board to check their assignments for a mandatory government programme known as the National Youth Service Corps (NYSC).
"It was a huge crowd and people were jostling to go through the lists," said witness Isyaku Adamu.
Accounting student Kabir Muazu told AFP he was sitting in a nearby lecture hall when a massive blast rang out.
"We all rushed to find out what it was," and saw the damage of the latest suicide attack in the embattled city, he said.
Kano has been hit by Boko Haram repeatedly through the group's uprising aimed at creating a strict Islamic state in the mainly Muslim country.
But the city saw a clear decline in violence earlier this year, as the Islamists appeared to be concentrating on their stronghold in the remote northeast.
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