The jihadist group has already lost more than half of its nearby bastion of Raqa to attacking US-backed forces, and the loss of Deir Ezzor city and the surrounding oil-rich province would leave it with only a handful of isolated outposts.
Deir Ezzor province borders Iraq, where IS has also been expelled from former strongholds Mosul and Tal Afar.
The jihadists hold large parts of Deir Ezzor province, and more than half the provincial capital Deir Ezzor city, the remainder of which is controlled by the government and under IS siege.
By today afternoon, Syrian state media said troops were swiftly approaching the city.
"The Syrian army has advanced towards Deir Ezzor to break the siege on it and is now just three kilometres (nearly two miles) from the city," a breaking news alert on state television said.
The Britain-based Syrian Observatory for Human Rights monitoring group said Syrian troops and allied fighters had arrived at the Brigade 137 base on the western outskirts of the city, and were battling to reach troops besieged by IS inside.
"The siege on the government troops will be broken within hours," the source added.
Syrian troops were also quickly advancing on another front, said the Observatory, adding they were some 12 kilometres from Deir Ezzor's besieged military airport.
Provincial governor Mohamed Ibrahim Samra, quoted by state news agency SANA, said besieged residents were already celebrating as the army neared.
"Yesterday Deir Ezzor city saw celebrations and rejoicing among all segments of society ahead of the expected victory with the advance of the Syrian Arab Army to the outskirts of the besieged city," he said.
"The fall of IS in Deir Ezzor will be a strategic defeat for the international terrorist group in Syria," the ministry said in a statement.
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