"For the first time, the army today used drones received from Moscow in operations against extremists in the north and east of the country," the source said, without elaborating on the type of drones or locating exactly where they were deployed.
In Moscow, Kremlin spokesman Dmitry Peskov declined to comment on the report, news agency RIA Novosti said.
The deployment came amid a Russian military build-up in Syria, over which the United States has expressed deep concern.
"Russian weapons are starting to have an effect in Syria," the official told AFP.
The official added that President Bashar al-Assad's forces had already been using these weapons against the Islamic State group in the cities of Deir Ezzor and Raqa, the IS de facto capital in Syria.
Assad's forces have stepped up air strikes in the past week, killing at least 38 IS jihadists in central Syria, especially Palmyra, according to the Syrian Observatory for Human Rights.
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