The figures released by Centcom, the US military command in the Middle East, came from a months-long review of reports and databases, it said yesterday, adding that the deaths and injuries stemmed from 24 air strikes.
London-based NGO Airways estimates coalition bombing has killed 1,787 civilians since the air campaign to destroy the Islamic State group began in August 2014.
"We have teams who work full time to prevent unintended civilian casualties," Colonel John Thomas was quoted as saying in the Centcom statement.
The Pentagon's investigation found that "in each of these strikes the right processes were followed; each complied with Law of Armed Conflict and significant precautions were taken, despite the unfortunate outcome," Thomas said.
The United States, which carries out 80 per cent of the coalition bombing, says it uses precision-guided munitions that limit civilian casualties.
Meanwhile Russia is accused of using conventional bombs that are much more deadly to civilian populations.
Amnesty International estimates that there have been at least 300 civilian victims in Syria alone from coalition strikes.
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