The bank's wealth management unit also turned in a strong fourth quarter with revenue rising more than 10% to $6.25 billion.
Dealmaking activity is expected to remain robust despite the prospect of debt becoming costlier, while Main Street lenders are expected to post healthier profits from consumer lending as interest rates are likely to rise later this year.
Morgan Stanley, which advised on 420 deals last year, ranked third in the global investment banking league tables, following larger rivals Goldman Sachs and JPMorgan Chase, according to data from Dealogic.
League tables rank financial services firms based on the amount of investment banking advisory fees they generate.
While equity underwriting revenue was down from last year, Morgan Stanley still advised on some of the biggest initial public offerings, including Amazon-backed electric vehicle maker Rivian Automotive Inc, to generate $53 million during the quarter.
In 2021, Wall Street investment banking giants rode the dealmaking wave and advised on several major business combinations and helped put together deals involving special purpose acquisition companies.
Profit rose to $3.59 billion, or $2.01 per share, in the quarter ended Dec. 31, from $3.27 billion, or $1.81 per share, a year earlier.
Analysts on average were expecting the bank to report a profit of $1.91 per share, according to IBES data from Refinitiv.
Revenue rose to $14.52 billion on for the quarter compared with $13.59 billion in the year-ago period.
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